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CBD for improving our Brain Health

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CBD, or cannabidiol, is the most famous and beneficial amongst the compounds found in Cannabis or marijuana. This specific cannabinoid has a huge potential scope of benefits in therapeutic applications including both physical and mental none of which involve getting high or compromising your short-term memory.

Let’s take a detailed tour on that what benefits can CBD offer on HUMAN BRAIN based on proven scientific medical studies.The Human Brain is very complicated and has been always the centre of attraction of scientific community. Actually, there is an ever-growing research community to explore the effects of cannabinoids on our mind blowing and complicated than astrophysics Brain. The first big breakthrough came in 1960s. A team of Israeli Scientists led by Dr. Raphael Mechulam.They discovered the chemical structure of CBD and THC, the very basic compound found in cannabis.

In 1992 another major breakthrough came at the Hebrew University in Jerusalem, Dr. Lumir Hanus along with American researcher Dr. William Devane discovered the endocannabinoid system in human brain which is remarkably responsive to cannabis especially cannabinoids and cannabidiols revealing numerous medical benefits on human brain and mind.With all these complicated chemical interaction CBD improves potential brain health reducing anxiety, depression and improves mood. A recent paper published in the British Journal of Clinical Pharmacology, CBD has the following benefits for our brain health:

1. Antiemetic which reduces nausea and vomiting

2. Anticonvulsant which suppresses seizure activity.

3. Antipsychotic which fights psychosis.

4. Anti-inflammatory (decreases inflammation).

5. Antioxidant (combats oxidative stress).

6. Anti-tumoral, Anti-cancer (combats tumor, cancer cell growth).

7. Anxiolytic, Antidepressant (combats anxiety and depression).

An international group of scientists including University of Melbourne Chair of Pediatric Neurology and Austin Health Director of Pediatrics, Professor Ingrid Scheffer, considered cannabidiol for the treatment of seizures. A recent study published in The New England Journal of Medicine stated that cannabidiol (CBD) as an effective anti-seizure drug for epileptic disorder.

Another study conducted at Virginia Commonwealth University shows that, cannabinoids can decrease seizures via the activation of the brain’s CB1 receptors, which are found in the memory-related areas of the brain and within the nervous system.

We know there is no cure discovered for autism yet. So, the autism treatment means actuality the treatment of major symptoms of autism. The followings are the most common symptoms and disorders create the core effects like deficiency in social interaction and communication, as well as repetitive behaviour for autism patients. They all can be cured by CBD.

Anxiety and depression are very common in autistic people both young and adult patients. Scientist proved that CBD is an ideal natural anxiolytic agent can successfully treat both anxiety and depression. Generally, both symptoms go hand in hand CBD works in the following ways. CBD interlocks the webs the 5-HT1A receptors found on our Endocannabinoid system which is responsible for reducing anxiety and stress.

It also prevents our natural negative response to stress without any side-effects [1]. CBD make the serotonin levels high by decreasing serotonin reabsorption in the brain.

Higher serotonin levels increase the feelings of happiness and well-being. CBD reduces anxiety and depression-like behaviours by triggering a mechanism named as hippocampal neurogenesis which increases growth of new cells in the hippocampal area of our brain, through activation of the CB1 and CB2 cannabinoid receptors [2].

CBD has a prehadronic effect which keeps our mind clam and reduces negativity

Many patients go through a frequent problem of shortage of sleep as a result of melatonin imbalance. For the relaxing and calming properties of CBD, its effect on sleep is very beneficial. CBD can increase our average sleep time by controlling the sleep-wake cycle. By taking in balanced dose CBD has no sedative side effect and keeps you alert during the day [4].

When it comes to self-medicating or living a sound mental health, its important to understand no available mainstream medication is free from biological or chemical side effects because every action has an equal and opposite reaction (just read the side effects on the label of any pill bottle at the pharmacy).

The fact is, Aspirin kills over 1,000 people every year, and alcohol kills over 110,000 people, but nobody has ever died from CBD or marijuana.

In past few years many scientific studies on CBD gave the evidence confirming CBD as a potentially effective treatment in many metal issues and good for our brain health. Now it’s your time to think out of the box made by the politicians and pharmaceutical syndicates and pay attention to your wellbeing and happiness.

References:

[1] Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors.

Authored by: Zanelati TV1, Biojone C, Moreira FA, Guimarães FS, Joca SR.

[2] Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
Authored by: Wen Jiang, Yun Zhang, Lan Xiao, Jamie Van Cleemput, Shao-Ping Ji, Guang Bai, and Xia Zhang.
[4] Cannabis, Cannabinoids, and Sleep: a Review of the Literature.
Authored by: Babson KA1, Sottile J2, Morabito D3.
Martin-Santos, R., Crippa, J. A., Batalla, A., Bhattacharyya, S., Atakan, Z., Borgwardt, S., … & Zuardi, A. W. (2012). Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers.
Current pharmaceutical design, 18(32), 4966.
de Souza Crippa, J. A., Zuardi, A. W., Garrido, G. E., Wichert-Ana, L., Guarnieri, R., Ferrari, L., … & McGuire, P. K. (2004).
Neuropsychopharmacology, 29(2), 417.
Fusar-Poli, P., Allen, P., Bhattacharyya, S., Crippa, J. A., Mechelli, A., Borgwardt, S., … & Zuardi, A. W. (2010). Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol.
International journal of neuropsychopharmacology, 13(4), 421-432.
Hill, M. N., Patel, S., Carrier, E. J., Rademacher, D. J., Ormerod, B. K., Hillard, C. J., & Gorzalka, B. B. (2005)
Neuropsychopharmacology, 30(3), 508-515.
Chagas, M. H. N., Crippa, J. A. S., Zuardi, A. W., Hallak, J. E., Machado-de-Sousa, J. P., Hirotsu, C., … & Andersen, M. L. (2013). Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats.
Journal of Psychopharmacology, 27(3), 312-316.
Devinsky, O., Marsh, E., Friedman, D., Thiele, E., Laux, L., Sullivan, J., … & Wong, M. (2016). Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. The Lancet Neurology, 15(3), 270-278.
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