Posted on Leave a comment

CBD vs Heart Disease

cbd vs heart disease
Facebook
Twitter
Instagram

Heart Disease; the reality is it can happen to anybody at any time, and for a multitude of reasons. Heart diseases can involve blocked, corroded, and/or narrowed blood vessels, and sometimes it occurs in the heart muscle itself, while other times it “settles” in the valves.

Picture credit: gbi research

Also known as cannabidiol, CBD is a marijuana- or hemp-based solution that offers the users medicinal value without the related high.  It is also well-documented to interact positively with the endocannabinoid system (ECS) of the human body by binding with two primary receptors affecting the heart – CB1 and CB2.  Vaping CBD stimulates these receptors to become more active than they usually would be otherwise.  

Study find that CBD is such type of natural chemical compound which can be used for prevention of heart disease.

 CBD and Cardiovascular Disease

CBD was also found to act as an agonist (a compound that boosts the effects of a different compound in the body) for a compound called PPARγ, which helps clear blockages in the arteries and reduces blood pressure.  This means that CBD acts on the cardiovascular system in (at least) two ways: it relaxes the blood vessels themselves, and it helps boost the activity of compounds that reduce blood pressure and gradually clear blockages. The anxiolytic (anti-anxiety) effects of CBD can also benefit cardiovascular health by decreasing cardiac response to stress, reducing the likelihood of a sudden cardiac event, like a heart attack. CBD can help regulate an irregular heartbeat further reducing your risk of heart attack—especially if you’ve been diagnosed with an arrhythmia. These studies suggest that CBD has a regulatory effect on heart rate, and it does not appear to raise heart rate

Reducing Inflammation

CBD is well-known for its potential to reduce harmful inflammation. The 2-AG endocannabinoid binds to the CB2 receptor, and this causes the immune system to send out less immune cells to attack. Also, CBD has proven to reduce the number of cells that die in the heart during inflammation. This helps your heart muscle hold onto its strength.

Lowering Blood Pressure

One of the main side effects associated with CBD is lowered blood pressure. In the case of heart disease, this is more of a treatment than a risk. CBD has been found to widen the blood vessels (allowing for more blood flow), and as a result, this reduces the damage that is done to arterial walls caused by high blood pressure. As part of the study, nine healthy males were given either CBD or placebo, and it was discovered that those who took the CBD experienced reduced stroke volume, reduced blood pressure after cold exposure, and reduced resting systolic pressure.

CBD to reduce plaque buildup in the arteries

The plaque buildup increases the patient’s health risks for a future stroke or heart attack.  Vaping CBD relaxes these arterial walls, reduces the related inflammation, and repairs the associated tissue damage.  Furthermore, according to research Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons, vaping CBD helps modulate glucose levels and reduce oxidative stress on the heart. 

CBD can provide relief to consumers that are suffering from a variety of conditions that adversely affect their quality of life. In fact, CBD may extend the lives of those suffering from high blood pressure and other serious heart disease.

Reference:

Baldassarri S, Bertoni A, Bagarotti A, Sarasso C, Zanfa M, Catani MV, et al. The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors. J Thromb Haemost. 2008;6:1772–1779. [PubMed]

Barnes CS, Coker SJ. Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaethetized rats. Br J Pharmacol. 1995;114:349–356. [PMC free article][PubMed]

Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001;134:845–852. [PMC free article][PubMed]

Clark C, Foreman MI, Kane KA, McDonald FM, Parratt JR. Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrrhythmias and for the determination of infarct size. J Pharmacol Methods. 1980;3:357–368. [PubMed]

Currie S, Rainbow RD, Ewart MA, Kitson S, Herradon-Pliego E, Kane KA, et al. IP3R-mediated Ca2+ release is modulated by anandamide in isolated cardiac nuclei. J Mol Cell Cardiol. 2008;45:804–811.[PubMed]

Ryberg E, Larsson N, Sjögren S, Hjorth S, Hermansson NO, Leonova J, et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007;152:1092–1101. [PMC free article] [PubMed]

Tamargo J, Caballero R, Gomez R, Valenzuela C, Delpon E. Pharmacology of cardiac potassium channels. Cardiovasc Res. 2004;62:9–33. [PubMed]

Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol. 2007;150:613–623. [PMC free article] [PubMed]

Facebook
Twitter
Instagram

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.